PHARMACEUTICAL WATER SYSTEMS, USP PURIFIED WATER SYSYEMS, PHARMACEUTICAL USP PURIFIED WATER SYSTEMS, ELECTRODEIONIZATION SYSTEM, EDI SYSTEM

Blue Spring Corporation manufactures USP Water for Injection systems

Bottles being filled with pharmaceutical product

With over 29 years of experience in USP water systems,
when you go with Blue Spring, you are in safe hands !
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* Closed-loop output option not available for these models.

1. Intended for formulation of pharmaceuticals and pharmaceutical ingredients, and for manufacturing of
medical devices.  Water purification equipment not intended for direct use as a medical device in medical
treatment.  Product water not intended for direct use as a drug in medical treatment.  On-site Installation
Qualification, Operational Qualification, Performance Qualification and long-term System Validation is
usually required, for establishing long-term consistency of product water quality, under seasonal variations
of feed water quality and operating conditions.

According to U.S. FDA, USP Purified Water and USP Water for Injection are components or “ingredient
materials” as they are termed by the USP, intended to be used in the production of drug products.  Neither
FDA nor USP considers them as drug products.  These two water categories are popularly used within
pharmaceutical and medical device manufacturing establishments.

2. All models except WP-800-EDI and WP-1600-EDI are fully cabinet enclosed.  In models WP-800-EDI and
WP-1600-EDI, reverse osmosis modules are attached externally to the cabinet.
NEW

WP-R-EDI SERIES PHARMACEUTICAL USP WATER SYSTEM

PRODUCES HIGH QUALITY PHARMACEUTICAL USP PURIFIED WATER PER USP 23-32
For WFI-EDI Series USP Water for Injection systems, click here

LATEST COMBINATION OF REVERSE OSMOSIS AND ELECTRODEIONIZATION TECHNOLOGIES WITH BUILT-IN, CLOSED-LOOP RECIRCULATION OUTPUT SYSTEM PRODUCES HIGH QUALITY PHARMACEUTICAL PURIFIED WATER PER USP 23-32

Blue Spring Corporation is the pioneer (1982) in commercialization of double-pass reverse osmosis technology for the production of pharmaceutical water systems per United States Pharmacopoeia. Now, with the addition of electrodeionization (EDI) technology and a storage-tank-less re-circulating closed loop output feature, the new breed of BLUE SPRING WP-R-EDI series pharmaceutical water purification systems produce even higher quality USP Purified Water which surpasses the latest USP 32 Purified Water1 standards.



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Exceptional Quality USP Purified Water:  Typical output water measures 0.3-1.0  microS/cm electrical conductivity, 150-200 ppb TOC, 1-10 cfu/ml bacteria content.  Consistently meets USP 23-32 Purified Water standards.
Exceptionally Consistent Water Quality:  Replacement of conventional de-ionizing resin beds with electrodeioning modules (EDI), results in highly consistent biopurity and lower ion content.
Exceptional Economy:  Costs fraction of conventional, distillation-based USP Purified Water  systems to purchase, to operate and to maintain.
Exceptionally Space-Saving Design:  Small 76 cm x 145 cm footprint for 1,600 L/hr capacity unit.
Sanitary Construction:  Fully enclosed
2
inside stainless-steel cabinet. High-purity, low-extractable PVC output piping, superior to PVDF or stainless-steel.
Ultimate Contamination Control:  Totally sealed system, including distribution network, prevents infusion of environmental contaminants.
Integrated Closed-Loop R
e-circulation
(optional):  Closed-Loop purified water distribution system (see below). Unused water from production area is continuously recycled to water purification section where it gets repeatedly purified with every pass. Continuously purges out bacteria and their endotoxins generated in pipelines, instead of accumulating them, as in conventional, storage-tank based delivery systems.
Exceptionally Simplified Distribution System Design:  Only a few passive piping components required for completing delivery system. No storage tanks, no breathing filters, no re-circulation pumps, no sub-micron filters required for delivery of USP Purified Water to multiple points of use.
Water-Saving Design:  60-70% overall water recovery.
Energy-Saving Design:  Only 4 watt.hours of total energy consumption per liter of purified water, including delivery system. Compare this with 80 - 230 watt.hours/liter energy consumption of conventional distillation stills.
Environmentally Friendly Design:  No chemicals used to regenerate de-ionizing resins. No chemical discharge to sewer other than impurities present in source water.
Easy Installation:  Integrated RO/EDI design for Plug-n-Go installation. Only pre-treatment components and simple, passive piping for delivery of purified water required to complete installation.
Easy Operation:  Single-switch daily operation with manual over-ride. Quick stabilization avoids 24/7 operation. Ergonomic instrumentation and control panel.
Easy Maintenance:  Only single moving part (RO pump), in the entire water system, including delivery loop piping.  Single circuit board electronics for all instrumentation. Integrated EDI power supply. Very few things to break down.

UNIQUE FEATURES

Easy Sanitizing:  Single-shot cold sanitizing of water purification unit and distribution loop piping, with built-in cleaning and sanitizing system. No steam generator required.
Easy Validation:  Factory-assembled, factory pre-qualified water purification units simplify on-site qualification and validation of the pharmaceutical process water system. Factory OQ and PQ certification provided with each system
       SPECIFICATIONS FOR WP-EDI SERIES USP PURIFIED WATER SYSTEMS
MODEL
WP-100-EDI*
WP-240-EDI
WP- 420-EDI
WP-800-EDI
WP-1600-EDI
SIZE
(W x D x H)
56 X 76 X 126 CM
68 x 118 x 148 CM
76 x 145 x 148 CM
91 x 236 x 152 CM
162 x 244 x 152 CM
SHIPPING WT.
135 KG
290 KG
365 KG
650 KG
1,000 KG
ELECTRICAL
220 VAC/
1 ph/8 A
460 VAC/
3 ph/6.5A
460 VAC/
3 ph/8A
460 VAC/
3ph/14A
460 VAC/
3ph/24A
SUPPLY
WATER
8.5-11 LPM
19-24 LPM
29-35 LPM
56-65 LPM
112-130 LPM
SUPPLY WATER
QUALITY
EPA quality municipal water. 20-60 psig pressure. 22-32oC temperature. Pre-softening of feed water required,
to reduce hardness below 5 mg/L. May require carbon filtration, if chlorine or other disinfectant is present in
feed water. Contact us for details.      
OUTPUT PORT
1/2" O.D. Tubing
3/4" High Purity
PVC Union Standard
1" High Purity PVC
Union Standard
1-1/4" High Purity
PVC Union Standard
1-1/2" High Purity
PVC Union Standard
OUTPUT FLOW
5.9-7 LPM
at 25 oC Water
Temp.
11.0-13.6 LPH
at 25 oC Water
Temp.
23.5-28.0 LPM
at 25 oC Water
Temp.
43-50 LPM
at 25 oC Water
Temp.
86-100 LPM
at 25 oC Water
Temp.
OUTPUT WATER
QUALITY
Output water meets Purified Water specifications per U.S.P.  Typical electrical conductivity  0.3 - 1 mS/cm, 
Typical TOC 150-200 ppb, Typical bacteria count 0-10 cfu/ml.  Note: day-to-day biological quality of  water
will depend on sanitizing schedule and general equipment maintenance.      

TYPICAL INSTALLATION OF BLUE SPRING WP-R-EDI PHARMACEUTICAL USP PURIFIED WATER SYSTEM
Schematic diagram explaining how closed loop USP Purified Water system works
Blue Spring WP-420R USP Purified Water System
Typical installation of Blue Spring WP-420R-EDI  USP Water System
Ideal for production of over-the-counter drugs, syrups, medicated creams and skin lotions, health supplements and naturals, vitamin products, active pharmaceutical ingredients (API)